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A non-synonymous coding variant (L616F) in the TLR5 gene is potentially associated with Crohn's disease and influences responses to bacterial flagellin.

机译：TLR5基因中的非同义编码变体（L616F）可能与克罗恩病相关并影响对细菌鞭毛蛋白的反应。

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Jared Sheridan; David R Mack; Devendra K Amre; David M Israel; Artem Cherkasov; Huifang Li; Guy Grimard; Theodore S Steiner;
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1. Protein Kinase D Interaction with TLR5 Is Required for Inflammatory Signaling in Response to Bacterial Flagellin. [J] . Ivison SM, Graham NR, Bernales CQ, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2007 ,第9期

机译：与细菌鞭毛蛋白反应的炎症信号需要与TLR5的蛋白激酶D相互作用。
2. Genetically determined high activity of IL-12 and IL-18 in ulcerative colitis and TLR5 in Crohns disease were associated with non-response to anti-TNF therapy. [J] . S Bank, P S Andersen, J Burisch, The pharmacogenomics journal . 2018 ,第1期

机译：在溃疡性结肠炎和Crohns病中的溃疡性结肠炎和TLR5中的IL-12和IL-18的高活性与抗TNF治疗的不反应相关。
3. Genetic susceptibility to increased bacterial translocation influences the response to biological therapy in patients with Crohn's disease [J] . GutiérrezA., ScharlM., SempereL., Gut: Journal of the British Society of Gastroenterology . 2014 ,第2期

机译：细菌易位性的遗传易感性影响克罗恩病患者对生物疗法的反应
4. The Blight-Resistance Gene Response to Bacterial Leaf Blight Disease in Isogenic Varieties through Pathogenicity Test [C] . Indra Kurniawan Saputra, I Made Artika, Tasliah International Conference on Life Sciences and Technology . 2020

机译：通过致病性试验对细菌叶片枯萎病的枯萎基因反应
5. Cellular immune response and gene expression profiling in Crohn's disease patients associated with Mycobacterium avium subspecies paratuberculosis [D] . Romero, Claudia M. 2004

机译：鸟分枝杆菌副结核分枝杆菌相关克罗恩病患者的细胞免疫应答和基因表达谱
6. A Non-Synonymous Coding Variant (L616F) in the TLR5 Gene Is Potentially Associated with Crohns Disease and Influences Responses to Bacterial Flagellin [O] . Jared Sheridan, David R. Mack, Devendra K. Amre, -1

机译：TLR5基因中的非同义编码变体（L616F）可能与克罗恩氏病相关并影响对细菌鞭毛蛋白的反应
7. Genetic susceptibility to increased bacterial translocation influences the response to biological therapy in patients with Crohn's disease [O] . Gutiérrez, Ana, Scharl, Michael, Sempere, Laura, 2014

机译：细菌易位性的遗传易感性影响克罗恩病患者对生物疗法的反应

A non-synonymous coding variant (L616F) in the TLR5 gene is potentially associated with Crohn's disease and influences responses to bacterial flagellin.

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